SCIENZE BIOMEDICHEAcademic Year 2017/2018 - 1° Year
- BIO/10 - BIOCHEMISTRY
- BIO/14 - PHARMACOLOGY
Term / Semester: 1°
The course aims to provide an appropriate preparation of biochemistry to the understanding of the structure and function of biological molecules and the meaning of the main metabolic events. After completing this module, students will learn general knowledge on the molecular basis of life, from the fundamental chemical properties of the substances, the structure and function of macromolecules involved in staying alive, both at the cellular and extracellular level , the metabolic transformations of biomolecules essential for the human body function. In addition, the student will know the meaning of changes in key metabolic pathways in different physiological and pathological contexts.
The aim of this course is the knowledge for the general mechanisms of drugs action, the principles of pharmacokinetics, the adverse effects and the more important pharmacological interactions. After completing this module, students gain understanding the main pharmacological and pharmacotherapeutic mechanisms of different classes of drugs.
Detailed Course Content
2. CHROMOPROTEINS AND THE TRASPORT OF OXYGEN
3. PLASMA PROTEIN AND THEIR CLINICAL IMPLICATIONS
4. ENZYMES AND ENZYMATIC CATALYSIS
5. THE CARBOHYDRATE METABOLISM
6. THE LIPID METABOLISM
7. THE METABOLISM AMINOACIDS
9. MECHANISM OF ACTION OF HORMONES AND METABOLIC INTEGRATIONS
Introduction to Pharmacology.
Drugs development process.
Elements of Pharmacokinetics: absorption, distribution, metabolism, elimination.
Elements of Pharmacodynamic and types of drug receptors.
Elements of drugs interaction.
Elements of drug abuse and addiction.
Allergy and idiosyncrasy.
Drugs and teratogenic risk.
Serotonergic, adrenergic and GABAergic neurotransmission.
Treatment of depressive and anxiety disorders.
Anti inflammatory agents.
Anti histaminic drugs.
Treatment of asthma and anaphylactic shock.
1. Introduzione alla Biochimica di Lehninger – D.L. Nelson, M.M. Cox – ZANICHELLI
2. Biochimica medica – Siliprandi, Tettamanti – PICCIN
Farmacologia per le professioni sanitarie; Rossi F., Cuomo V., Riccardi C.,
Edizioni Minerva Medica